cerium oxide toxicity

** Note that the RfC was quantified for cerium oxide particles with an MMAD of approximately 2 µm and a GSD of 1.8-1.9, and may not characterize the potential toxicity from exposures to cerium oxide particles with smaller mass median diameters and geometric standard deviations, including nano-sized cerium particles. Mix with water into a paste to create fast acting scratch remover. Cerium oxide (CeO2) nanoparticles are one among the high priority group. It is shown here that nanoparticles composed of cerium oxide or yttrium oxide protect nerve cells from oxidative stress and that the neuroprotection is independent of particle size. In this study, the acute and subchronic toxicity of CeO2-NPs were assessed. The sulforhodamine B method was employed to assess cell viability after exposure to 3.5, 10.5, and 23.3 microg/ml of CeO2 nanoparticles for 24, 48, and 72 h. In this study, male mice were examined for toxicity, if any, following chronic oral administration of CeO2 NPs for 32 days. 2022-01-15. There are contradictory reports on the effects of CeO 2 NPs, which may be related to the use of different types of nanoparticles (NPs) and coatings. Due to the wide range of applications of cerium oxide nanoparticles (CeO 2 NPs), a risk assessment of their biological effects using environmentally relevant species becomes highly important. North Alabama Reef Club. All new cars are now equipped with catalytic conveter which consist in a ceramic or metal substrate, a coating of aluminium and cerium oxides and a layer of finely dispersed . In this study we employed transgenic Caenorhabditis elegans (C. elegans) strains to assess the toxicity of CeO 2 nanoparticles under "real-world" conditions. Cerium exists both in the trivalent state (Ce3+, cerous) and very stable tetravalent state (Ce4+, ceric) as cerium oxide (CeO 2).1 CeO 2 This is diluted with diesel for delivery to the vehicle at a ratio of 1:4000, yielding a final cerium oxide concentration in the vehicle diesel fuel of 5 ppm. About BioCurity BioCurity Pharmaceuticals Inc. is a preclinical biotech company focused on developing novel mechanism-based nanoparticle drugs designed to transform radiation therapy for cancer patients worldwide. PRODUCT AND COMPANY IDENTIFICATION 1.1 Product identifiers Product name: Cerium Oxide (CeO2) Powder Product Number : US3036 Cerium Oxide (CeO2) CAS#: 1306-38-3 Cerium oxide nanoparticles (CeONPs) have attracted much attention because they possess multi-enzyme mimetic properties and have been used in bioanalysis, biomedicine, drug delivery, bioscaffold . At these concentrations, a moderate increase in the levels of enzymes released by the cells was observed, but the increase was not comparable in magnitude with effects on cell viability. Cerium oxide is part of the catalyst of catalytic converters used to clean up exhaust vehicles, it also catalyzes the reduction of nitrogen oxides (NO x) to nitrogen gas. It is also considered one of the rare-earth elements. CAS Number: 1345-13-7 / EC Number: 215-718-1 Company: Angstrom Sciences, Inc. It is a cerium molecular entity and a metal oxide. 2009. Abstract: With the development of many nanomedicines designed for tumor therapy, the diverse abilities of cerium oxide nanoparticles (CONPs) have encouraged researchers to pursue CONPs as a therapeutic agent to treat cancer. CiteSeerX - Document Details (Isaac Councill, Lee Giles, Pradeep Teregowda): With the fast development of nanotechnology, the nanomaterials start to cause people's attention for potential toxic effect. Since cerium oxide nanoparticles (CNPs) exhibit remarkable antioxidant capacities, our objective is to develop an innovative coating to enhance CNPs bio-compatibility without disrupting their. It is used for polishing glass, in coatings for infra-red filters to prevent reflection, and as an oxidant and catalyst in organic synthesis. Article Administrator. [9,10,15] Cerium oxide is also used as a glass constituent to prevent solarization and discoloration. IDENTIFICATION. It provides no warranties, either expressed or implied, and assumes no responsibility for the accuracy or completeness of the data . Cerium oxide nanoparticles (CeO2 NPs) have potential application for use in biomedical and in various consumer products. Toxicological Review of Cerium oxide and cerium compounds (CAS No. 904 studies in PubMed science library may include information on the toxicity of this chemical: NLM PubMed Cerium has no biological role in humans and is not very toxic. [10] Cerium oxide is also used in emission control systems in automobile engines as a diesel fuel-borne Moderator Emeritus. For instance, a study performed on the rat retina cells showed that nanoceria was found to be non-toxic. Cerium oxide was one of the first polishes to be widely used in rock tumbling.It is the "polish of choice" for many people who do rock tumbling and all types of lapidary work. Cerium dioxide (CeO 2) is an oxide of the rare-earth metal Cerium (chem. Cerium Compounds: Cerium compounds are mildly to moderately toxic, depending on the particular compound. Reef Tank 365. 2005-03-27. Cerium is a lanthanide element with atomic number of 58 which has two oxide forms including cerium dioxide (CeO 2) and di-cerium trioxide (Ce 2 O 3) [1-3]. Ceric oxide is a metal oxide with formula CeO2. Thus, the toxicological effects of these ENMs should be further studied. However, little attention has been paid as to whether CeO 2 NPs will have adverse effects on cyanobacteria. UV-induced toxicity of cerium oxide nanoparticles (CeO 2 NPs) and the protective properties of natural organic matter (NOM) from the Rio Negro Amazon River Y. Zhang, T. A. Blewett, A. L. Val and G. G. Goss, Environ. Non-nano cerium oxide powder (CeO 2) was used as a positive control for cerium toxicity. CERIUM OXIDE . Is this cerium oxide toxic? Cerium oxide nanoparticles (CNPs) have been shown to induce diverse biological effects, ranging from toxic to beneficial. Comparison of the mechanism of toxicity of zinc oxide and cerium oxide nanoparticles based on dissolution and oxidative stress properties. Product Name: Cerium Oxide . In this work, we investigated the toxicity effect of cerium oxide nanoparticles on ALT, ALP and AST enzymes of male Rat. Cerium oxide was about 100-fold less potent than cerium chloride. Nanoceria (cerium oxide nanoparticles) toxicity is currently a concern because of its use in motor vehicles in order to reduce carbon monoxide (CO), nitrogen oxides (NO x ), and hydrocarbons in exhaust gases. The cerium oxide nanoparticles synthesized and morphological properties of it such as UV-Vis spectrum exposure to toxic nanoparticles can be reduced through identifying creation-exposure pathways of toxins. Is cerium oxide toxic? Envirox™ is a cerium oxide based fuel borne catalyst and supplied as a dispersion of 2% w/v cerium oxide in a hydrocarbon carrier (which is wholly compatible with diesel). Cerium is a rare earth element belonging to the lanthanide series, possessing a stable cerium (IV) oxidation state that coexists with cerium (III). CeO 2 NPs may act as an oxidant causing toxicity or as . These NPs are of great concern because of potential toxicity towards human health and the environment. Build Thread Contributor. In the present study, CeO2 nanoparticles were synthesized by hydroxide-mediated method and were . The RfC for cerium oxide based on alveolar hyperplasia in the lung was calculated as follows: RfC = BMCLHEc-UF = .86mg/m3-1000 = 9 x 1CT4 mg/m3 (rounded to one significant figure) Note that the RfC was quantified for cerium oxide particles with an MMAD of approximately 2.0 um and a GSD from 1.8 to 1.9, and may not characterize the potential . In the nanoparticle form, cerium oxide atoms form a cubic crystalline fluorite lattice structure where Ce 3+ , and the compensating oxygen vacancies, localize at the nanoparticle surface ( 5 ). AbstractThere are many uncertainties regarding the hazard of nanosized particles compared to the bulk material of the parent chemical. Nanomaterials like cerium oxide and barium sulfate are frequently processed in industrial and consumer products and exposure of humans and other organisms is likely. Toxicity of Cerium Oxide Nanoparticles in Human Lung Cancer Cells Weisheng Lin Department of Chemistry and Environmental Research Center for Emerging Contaminants, University of Missouri-Rolla, Rolla, Missouri, USA Yue-wern Huang Department of Biological Sciences and Environmental Research Center for Emerging Contaminants, The production and applications of nanoparticles (NP) in diverse fields has steadily increased in recent decades; however, knowledge about risks of NP to human health and ecosystems is still scarce. Create. In applications cerium dioxide gives infrared filters their anti-reflection coatings and is found in colour television tubes. Introduction. The distinctive property of this material is its reversible conversion to a nonstoichiometric oxide. In each animal, epididymides were examined for sperm . In the current study, we report the influence of nine different physical and chemical parameters: pH, aeration and, concentrations of MgSO4, CaCl2, KCl, natural organic matter, fructose, nanoparticles and Escherichia coli, on the antibacterial activity of dextran . In spite of their applications, the toxicity of these NPs in biological/physiological environment is a major concern. Xia, T. et al. EPA/635/R-08/002F. Article Contributor. Dosing solutions were renewed daily for 3 days. Since cerium oxide nanoparticles (CNPs) exhibit remarkable antioxidant capacities, the objective is to develop an innovative coating to enhance CNPs biocompatibility without disrupting their antioxidant capacities or enhance their toxicity. These forms can convert to each other's. The cerium oxide are suitable for many industrial applications due to The extensive application of cerium oxide nanoparticles (CeO 2 NPs), a type of rare earth nanomaterial, led to pollution into aquatic environments. Sci. In this paper, the cytotoxicity and oxidative stress caused by 20-nm cerium oxide (CeO2) nanoparticles in cultured human lung cancer cells was investigated. DOI: 10.1007/s12011-015-0297-4 Corpus ID: 11795921. ACS nano 2, 2121-2134 (2008). CeO 2 NPs suspended in standard United States Environmental Protection Agency reconstituted moderately hard water, used to culture the C. elegans, quickly formed large polydisperse aggregates. Background: Nanomaterials like cerium oxide and barium sulfate are frequently processed in industrial and consumer products and exposure of humans and other organisms is likely. In this paper, the cytotoxicity and oxidative stress caused by 20-nm cerium oxide (CeO 2) nanoparticles in cultured human lung cancer cells was investigated.The sulforhodamine B method was employed to assess cell viability after exposure to 3.5, 10.5, and 23.3 μg/ml . When dilutions of this concentration were prepared, the effect was a slightly reduction of toxicity, as shown in Fig. For instance, a study performed on the rat retina cells showed that nanoceria was found to be non-toxic. In the case of the NPs studied, oxide cerium NPs exhibit a high toxicology for all the seeds tested at the maximum stable concentration (0.64 mg/ml). It is not intended to be a comprehensive treatise on the chemical or toxicological nature of cerium oxide and cerium compounds. SECTION 1. Based on this, finally, the intention is to propose solutions to design improved nanoparticles that will work more precisely in medicine and safely in society. Toxicity Of Zinc Oxide And Cerium Oxide Nanoparticles To Mesquite Jose Angel Hernandez Viezcas University of Texas at El Paso, jahernandez19@miners.utep.edu Follow this and additional works at:https://digitalcommons.utep.edu/open_etd Part of theEnvironmental Sciences Commons This is brought to you for free and open access by DigitalCommons@UTEP. However, it is largely unclear whether CeO2 NPs have effects on male reproductive function. Cerium oxide nanoparticles (CeO 2 NPs) are included in the Organisation for Economic Co-operation and Development (OECD) priority list of engineered nanomaterials for assessment of their environmental impact. Cerium(IV) oxide CAS-No. Present study aimed to understand the molecular mechanism underlying the toxicity of CeO 2 NPs on lung adenocarcinoma (A549) cells. 58 In contrast, cerium oxide was toxic to bronchial epithelial lung fibroblasts in culture, 59 but . Cerium oxide produces a bright polish on agate, jasper, quartz, petrified wood, obsidian, feldspar minerals and just about every rock, mineral, and glass that is processed in a rock tumbler. R2R Excellence Award. Cerium oxide (CeO(2)) and zinc oxide (ZnO) nanoparticles (NPs) are extensively used in a variety of instruments and consumer goods. Cerium Compounds: Cerium compounds are mildly to moderately toxic, depending on the particular compound. Afsaneh Nemati, Vahideh Assadollahi, Ilaria Peluso, Abolfazl Abbaszadeh, Mandana Beigi-boroujeni, Zahra Khanipur, Mohammadreza Gholami, " A Stereological Study of the Toxic Effects of Cerium Oxide during Pregnancy on Kidney Tissues in Neonatal NMRI Mice ", Oxidative Medicine and Cellular Longevity, vol. 65 Components This product does not contain any chemicals known to State of California to cause cancer, birth defects, or any other reproductive harm. US. Identification of the mechanisms that drive the toxicity of TiO2 particulates: the contribution of physicochemical characteristics By FABIAN BERMUDEZ Comparative hazard identification of nano- and micro-sized cerium oxide particles based on 28-day inhalation studies in rats 58 In contrast, cerium oxide was toxic to bronchial epithelial lung fibroblasts in culture, 59 but . The present study was carried out to assess the CeO 2 NP toxicity to the freshwater midge Chironomus riparius larvae at concentrations of 2.5, 25, 250, and 2500 mg of CeO 2 NP/kg of sediment. 57 Similarly, the results of another study stated the non-toxicity of 2,000 mg/kg body weight per day of CNPs that was administrated orally. SAFETY DATA SHEET . Xia, T. et al. Cerium oxide nanoparticles in cancer. The aim is the identification of a putative prenatal toxicity of selected NM. ACS nano 2, 2121-2134 (2008). SF-1 mediates reproductive toxicity induced by Cerium oxide nanoparticles in male mice These results reveal the male reproductive toxicity of chronic exposure of CeO₂ NPs in mice, hinting that the utilization of CeO₂ NPs need to be carefully evaluated about their potential reproductive toxicity on the human health. Here, the authors assess the comparative hazard of two nanoscale (NM-211 and NM-212) and one microscale (NM-213) cerium oxide materials in 28-day inhalation toxicity studies in rats (according to Organisation for Economic Co-operation and Development technical . Joined Aug 14, 2016 Messages 22,489 Reaction score 60,766 . Environmental Protection Agency. Generally less information is given on health effects and toxicity, especially regarding long-term exposure to low nanoparticle doses. The UIC researchers plan to test the potential toxicity of the nanoparticles using cell lines of the lower digestive tract. 2. 16. In this study, we assessed potential toxicity of two commercially used engineered nanoparticles (ENP), titanium dioxide (TiO2) and cerium oxide (CeO), using thale cress Arabidopsis thaliana as a . These NPs are of great concern because of potential toxicity towards human health and the environment. Cerium Oxide (CeO2) Nanopowder / Nanoparticles US Research Nanomaterials, Inc. www.us-nano.com SAFTY DATA SHEET Revised Date 1/31/2017 1. for the hazard and dose-response assessment in IRIS pertaining to chronic exposure to cerium oxide and cerium compounds. investigated. Use Cerium Oxide with Felt Polishing Wheel to remove scratches and scuff marks in glass and mirror. Title:Multi-organ Toxicity Attenuation by Cerium Oxide and Yttrium Oxide Nanoparticles: Comparing the Beneficial Effects on Tissues Oxidative Damage Induced by Sub-acute Exposure to Diazinon VOLUME: 8 ISSUE: 3 Author(s):Mona Navaei-Nigjeh, Marzieh Daniali, Mahban Rahimifard and Mohammad R. Khaksar* Affiliation:Pharmaceutical Sciences Research Center, The Institute of Pharmaceutical Sciences . CeO 2 is widely used in abrasives for optical glass and glass substrates for liquid crystal displays and hard disks. With the fast development of nanotechnology, the nanomaterials start to cause people's attention for potential toxic effect. 1306-38-3 Revision Date California Prop. In high concentration, cerium oxide compete with the essential nutrients and reduce their uptake in plants. Cerium is the second element in the lanthanide series, and while it often shows the +3 oxidation state characteristic of the series, it also has a stable +4 state that does not oxidize water. Cerium oxide nanoparticles (CeONP) can be used to treat or prevent neurodegenerative diseases, including for example Alzheimer's Disease, Parkinson's Disease, Huntington's Disease, AIDS-related dementia, ALS, progressive supranuclear palsy, and encephalitis, as well as mitochondrial diseases and diseases associated with mitochondrial damage. Cerium oxide is used as a polishing agent for glass mirrors, plate glass, television tubes, ophthalmic lenses, and precision optics. Cerium oxide (CeO(2)) and zinc oxide (ZnO) nanoparticles (NPs) are extensively used in a variety of instruments and consumer goods. Cerium oxide nanoparticles (CeO2-NPs) are one of most exploited ENM in the industry due to their excellent catalytic and multi-enzyme mimetic properties. Generally less information is given on health effects and toxicity, especially regarding long-term exposure to low nanoparticle doses. It is a pale yellow-white powder with the chemical formula CeO 2. The use of the RfC for cerium The responses of cells exposed to nanoparticles have been studied with regard to toxicity, but very little attention has been paid to the possibility that some types of particles can protect cells from various . In an animal study, cerium carbonate, cerium fluoride, and cerium oxide were not found to be acutely toxic, showed no signs of dermal irritation, and were minimally irritating to eyes. (Cerium(IV) oxide) SECTION 12: ECOLOGICAL INFORMATION 12.1 Toxicity Toxicity to fish Semi-static test EC50 - Danio rerio (zebra fish) - > 200 mg/l - 72h(Cerium(IV) oxide) Toxicity to daphnia and other aquatic invertebrates Immobilization EC50 - Daphnia magna (Water flea) - > 1,000 Impact of cerium oxide nanoparticles shape on their in vitro cellular toxicity Valérie Forest *a,b,c , Lara Leclerc a,b,c , Jean-François Hochepied d,e , Adeline Trouvé d,e , Gwendoline Sarry a . Administration of cerium oxide nanoparticles at 1,000 times the effective dose did not produce toxicity in a small animal model. The present work aimed Recent data suggest that CeO2 nanoparticles may be toxic to lung cell lines in vitro and lung tissues in vivo. Cerium(IV) oxide, also known as ceric oxide, ceric dioxide, ceria, cerium oxide or cerium dioxide, is an oxide of the rare-earth metal cerium. 'That is our next set of studies,' says Pesavento, 'because [toxicity] is something . Ce), which belongs to the lanthanide group.Technical grade CeO 2 is generally present as micro- or nanoscale white to light yellow powder [1].. In the use of this concentration were prepared, the results of another study stated the non-toxicity of 2,000 body. Humans and is not intended to be a comprehensive treatise on the chemical or toxicological nature of cerium oxide toxic... Contrast, cerium oxide nanoparticle: a Lapidary Polish for Rocks and glass substrates for liquid crystal and. 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